Reviews FAO/WHO 50, 52 (see part 2 of the Bibliography). Oral Acute oral LD50 for rats 1517, mice 1490 mg/kg. Skin and eye Acute
percutaneous LD50 for rats >4000, rabbits >6000 mg/kg. Non-irritating to skin and eyes (rabbits). Skin sensitiser (guinea pigs).
Inhalation LC50 (4 h) for rats >5800 mg/m3. NOEL (2 y) for rats 3.6, mice 10 mg/kg b.w. daily; (1 y) for dogs 1.9 mg/kg b.w.
daily. ADI (JMPR) 0.04 mg/kg b.w. [1987]; (Syngenta) 0.02 mg/kg b.w. Other Not mutagenic, not teratogenic. No carcinogenic
potential of relevance for human exposure. Toxicity class WHO (a.i.) II EC classification Draft 29th ATP proposes Xn; R22| R43| N;
R50, R53

Biochemistry Steroid demethylation (ergosterol biosynthesis) inhibitor. Mode of action Systemic foliar fungicide with protective
and curative action, with translocation acropetally in the xylem. Uses Systemic foliar fungicide with a broad range of activity,
at 100-150 g/ha. On cereals, it controls diseases caused by Cochliobolus sativus, Erysiphe graminis, Leptosphaeria nodorum,
Puccinia spp., Pyrenophora teres, Pyrenophora tritici-repentis, Rhynchosporium secalis, and Septoria spp. In bananas, control of
Mycosphaerella musicola and Mycosphaerella fijiensis var. difformis. Other uses are in turf against Sclerotinia homoeocarpa,
Rhizoctonia solani, Puccinia spp. and Erysiphe graminis; in rice against Rhizoctonia solani, Helminthosporium oryzae, and dirty
panicle complex; in coffee against Hemileia vastatrix; in peanuts against Cercospora spp.; in stone fruit against Monilinia spp.,
Podosphaera spp., Sphaerotheca spp. and Tranzschelia spp.; in maize against Helminthosporium spp. Formulation types EC; SC; GL.
Selected products: 'Tilt' (Syngenta, Makhteshim-Agan); 'Bolt' (Barclay); 'Bumper' (Makhteshim-Agan); 'Juno' (Milenia); 'Menphis'
(Rocca); 'Propivap' (Vapco); mixtures: 'Stereo' (+ cyprodinil) (Syngenta); 'Stratego' (+ trifloxystrobin) (Bayer CropScience)